EDUCATIO
09/76- 06/81 College of Mathematics-Physics , Resita , Romania
BS Mathematics-Physics. Graduated Summa cum laude
09/81-09/87 University of Timisoara School of Medicine , Timisoara , Romania
M.D. Graduated Summa cum laude
9/95-11/01 University of Timisoara , School of Medicine , Timisoara , Romania
Ph.D. in Molecular Biology. Graduated Summa cum laude
11/87-9/90 Resident in Family Medicine, University Hospital Timisoara , Romania
9/90-12/93 Resident in Internal Medicine, Department of Internal Medicine at University Hospital, Timisoara, Romania.
9/95-8/98 Research fellow, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan , Medical Center , Ann Arbor , Michigan .
9/98-8/01 Clinical fellow, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, MI.
10/1987 General Medicine, Board Certified in Romania
01/1994 Internal Medicine, Board Certified in Romania
03/1998 ECFMG Educational Commission for Foreign Medical Graduates (certified)
03/2001 American Association for Clinical Endocrinology, Accreditation in Thyroid Ultrasound
07/2001 USMLE, Final licensure examination
Michigan Medical License (#4301071294
Ohio Medical License (#79991)
10/90-11/97 Assistant Professor of Internal Medicine, University of Timisoara, School of Medicine, Department of Internal Medicine, Division of Diabetes, Nutrition and Metabolic Disorders, Timisoara, Romania.
10/01- 06/05 Assistant Professor of Medicine and Physiology, Division of Endocrinology and Metabolism, Medical College of Ohio, Toledo, Ohio
03/04-06/05 Faculty member of the Graduate School at The Medical College of Ohio
07/05- Assistant Professor of Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes (MEND), University of Michigan Medical School, Ann Arbor, Michigan.
11/05- Associate Director, Neuropathy Center , University of Michigan Medical Center
CLINICAL/HOSPITAL APPOINTMENTS
11/93-11/97 Attending physician Department of Medicine, University Hospital Timisoara, Romania
10/01-6/05 Attending physician, Department of Medicine, Medical College of Ohio, Toledo
07/05- Attending physician, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
Dr. Pop-Busui research interests extend from the elucidation of the mechanisms underlying the development of diabetic complications to the design and execution of clinical trials to assess the efficacy of new therapeutic interventions. Dr. Pop-Busui has been and is a site PI on many major clinical trials sponsored by NIH such as ACCORD, BARI 2D and DCCT/EDIC and NEUROEDIC and by the Juvenile Diabetes Research Foundation. She is also PI on grants from the National Institute of Health exploring the role of cylcooxygenase-2 in the development of peripheral diabetic neuropathy and from the American Diabetes Association exploring the relationship between components of the metabolic syndrome, in the presence of prediabetic range glucose elevations, and oxidative stress in the development of cardiac autonomic neuropathy and the effects of a lifestyle interventions in subjects with metabolic syndrome. She is actively involved in studying the development of new treatments and diagnostic evaluations for diabetes and diabetic complications with emphasis on diabetic neuropathy and to assess the efficacy of various therapeutic interventions designed to halt or reverse the progression of chronic diabetic complications and especially of diabetic neuropathies.
HONORS AND AWARDS
1985 University of Timisoara School of Medicine , Honorary Award in Internal Medicine
1995 Fulbright Award
2001 American Diabetes Association Endocrinology Fellow of Excellence
01/04-06/05 Member of the MCO President Advisory Council for Research
05/2004-pres Member of the Council for Clinical Research of the American Association of Clinical Endocrinologist (AACE)
10/04-6/05 Member of the Research Advisory Committee for the Office of Inter Universities Research Collaboration of Ohio
2005 Member of the 2005 Peer Review Committees of the American Heart Association Co-chair
July 2005 University of Michigan Clinical Science Scholar Award
International Societies:
1995-present American Diabetes Association
1998-present Endocrine Society
1999-present American Association of Clinical Endocrinologist
2001-present American Medical Association
2003-present American Heart Association
1993-present European Association for the Study of Diabetes
1998-present NEURODIAB
1993-1994 European Association for the Study of Obesity
1990-1995 Balcanic Medical Association
National Societies:
1990-present Romanian Diabetic Association
12/04 Member of the 2005 Peer Review Committees of the American Heart Association Co-chair
03/2006 Member of the Editorial Board of Experimental Diabetes Research
11/2006 Member of the Editorial Board of Review of Endocrinology
03/07 Reviewer for Journal of Clinical Endocrinology and Metabolism
07/07 Reviewer for Journal of the Peripheral Nervous System
1. Rodica Pop-Busui, Bacanu GH, Sporea I: Detection of early gastric emptying showing in patients with long-standing diabetes by ultrasonography. Romanian Diabetes Association Annual Meeting, Brasov , Romania . March 1994.
2. Rodica Pop-Busui, Bacanu GH, Sporea I. Effect of cisapride and erythromicine on gastric emptying in diabetic patients. Romanian Diabetic Association Annual Meeting, Bucharest , Romania . March 1995.
3. Rodica Pop-Busui ,Van Huysen C, Beyer L, Towns R, Greene DA, Stevens, MJ: Dissociation of nerve blood flow and nerve conduction velocity by acetyl-L-carnintine treatment in streptozotocin diabetes. 56 th American Diabetic Association’s Annual Meeting, San Francisco , CA . June 1996.
4. Rodica Pop-Busui: Down-regulation of sciatic nerve Na+-taurine co-transporter in streptozotocin-diabetic rats – a potential mediator of glucose-toxicity. 8 th NEURODIAB Meeting, Sitges , Spain . September 1998.
5. Rodica Pop-Busui: Down-regulation of sciatic nerve Na+-taurine co-transporter in streptozotocin-diabetic rats – a potential mediator of glucose-toxicity. 34 th Annual Meeting of the European Association for the Study of Diabetes, Barcelona , Spain . September 1998.
6. Rodica Pop-Busui: Myocardial endothelial dysfunction complicates sympathetic dysinnervation in diabetic autonomic neuropathy. 59 th Annual Scientific Session of the American Diabetes Association, San Diego , CA June 1999.
7. Rodica Pop-Busui: Metabolic, vascular and nerve conduction deficits induced by cyclooxygenase inhibition in experimental diabetes. 60 th Annual Scientific Session of the American Diabetes Association, San Antonio , TX June 2000.
8. Rodica Pop-Busui: A case of amiodarone induced thyrotoxicosis. 82 nd Annual Meeting of the Endocrine Society, Toronto , Canada June 2000.
9. Rodica Pop-Busui: Taurine replacement prevents apoptosis in experimental diabetic neuropathy. Fifth Diabetic Neuropathy Satellite to the International Diabetes Federation Congress 2000, San Jose , Costa Rica. November 2000.
10. Rodica Pop-Busui: The Diabetic Foot. Professional Symposia of the Regional Association of the Outpatients Surgeons of Hessia, Frankfurt , Germany February 2001.
11. Rodica Pop-Busui, Marinescu V, Sullivan K, Larkin D, Li F and Stevens MJ: Cyclooxygenase (COX)-2 expression is selectively increased in the sciatic nerve of streptozotocin diabetic (STZ-D) rats. 61 st Annual Scientific Session of the American Diabetes Association, Philadelphia , PA June 2001.
12. Rodica Pop-Busui, Raffel D and Stevens MJ: Oxidative Stress is associated with abnormal myocardial blood flow regulation in subjects with Type 1 diabetes and microangiopathy. 61 st Annual Scientific Session of the American Diabetes Association, Philadelphia , PA June 2001.
13. Rodica Pop-Busui, Raffel D, Schroeder J and Stevens MJ: C-reactive protein is associated with abnormal myocardial blood flow regulation in subjects with Type 1 Diabetes and Microangiopathy. 62nd Annual Scientific Session of the American Diabetes Association, San Francisco , CA June 12, 2002
14. Rodica Pop-Busui, Raffel D, Schroeder J and Stevens MJ: Oxidative stress adrenergic hyper-reactivity and endothelial dysfunction complicating Type 1 Diabetes. NEURODIAB Annual Meeting, Balaton-Fured , Hungary August 30, 2002 .
15. Rodica Pop-Busui: Cyclooxygenase pathway and peripheral diabetic neuropathy. Brazilian Diabetes Association Annual Meeting, Porto Alegre , Brazil , December 2002.
16. Rodica Pop-Busui: Protein kinase C and diabetes complications Brazilian Diabetes Association Annual Meeting, Porto Alegre , Brazil , December 2002.
17. Rodica Pop-Busui: Kellogg A, Li F, Larkin D and Stevens MJ. Cox-2-Knock-Out Mice Are Protected From Nerve Conduction Velocity Slowing In Experimental Diabetes. 63 rd American Diabetes Association Annual Meeting, New Orleans , June 2003.
18. Rodica Pop-Busui, Kellogg A, Li F, Larkin D and Stevens MJ: Cox-2-Knock-Out Mice Are Protected From Nerve Conduction Velocity Slowing In Experimental Diabetes. NEURODIAB Annual Meeting, Saint-Malo , France , August 2003.
19. Stevens MJ, Schroeder J, Raffel D and Rodica Pop-Busui: Adrenergic Hyper-Responsiveness and Paradoxical Myocardial Blood Flow Regulation Complicate Type 1 but Not Type 2 Diabetes Mellitus. NEURODIAB Annual Meeting, Saint-Malo , France , August 2003.
20. Rodica Pop-Busui: Effects of COX-2 Gene Inactivation on Nerve Conduction Velocity and Oxidative Stress in Experimental Diabetes. 64 th American Diabetes Association Annual Meeting, Orlando , FL , June 2004.
21. Rodica Pop-Busui: An Update in Diabetic Neuropathies: From Glucotoxicity to Oxidative Stress and Beyond. Department of Diabetes and Cardiovascular Diseases Special Grand Round Presentation, Bad Oyehausen , Germany , September 1 st 2004 .
22. Rodica Pop-Busui: Effects of COX-2 Gene Inactivation on Nerve Conduction Velocity and Oxidative Stress in Experimental Diabetes II. Joint Meeting of NEURODIAB and Diabetic Foot Study Group of the EASD, Regensburg , Germany , September 3 rd 2004 .
23. Rodica Pop-Busui: Cyclooxygenase (COX)-2 Selective Inhibition, Oxidative Stress and Inflammation in Experimental Diabetic Peripheral Neuropathy. 65 th American Diabetes Association Annual Meeting, San Diego CA , June 2005.
24. Rodica Pop-Busui: Effects of Cyclooxygenase (COX) Inhibition on Nerve Conduction Velocity (NCV) and Sensory Fiber Function in Experimental Diabetes.15 th Annual Meeting of the NEURODIAB, Porto Heli Greece , September 2005.
25. Rodica Pop-Busui: Protective Effects of Cyclooxygenase-2 (COX-2) Gene Inactivation on Functional and Biochemical Deficits of Experimental Diabetic Neuropathy are Maintained after Longer Diabetes Duration.15 th Annual Meeting of the NEURODIAB, Porto Heli Greece , September 2005.
26. Rodica Pop-Busui: Effects of Cyclooxygenase-2 (COX-2) Gene Inactivation on Myocardial Oxidative Stress and Inflammation in Experimental Diabetes. American Heart Association Scientific Session, Dallas, 2005.
27. Rodica Pop-Busui.: Long Term Protective Effects of Cyclooxygenase-2 (COX-2) Gene Inactivation on Functional Deficits of Experimental Diabetic Neuropathy. 66 th American Diabetes Association Annual Meeting, Washington DC , June 2006.
28. Rodica Pop-Busui: Oxidative Stress and Cardiovascular Denervation in Diabetes: An Interventional Trial. 16 th Annual Meeting of the NEURODIAB, Ystad , Sweden , September 2006.
29. Rodica Pop-Busui: Cross Talk between Cyclooxygenase-2 (COX-2) pathway, oxidative stress and inflammation in long term experimental diabetic neuropathy. 16 th Annual Meeting of the NEURODIAB, Ystad , Sweden , September 2006.
30. Rodica Pop-Busui: Kellogg AP, Hayes J, Larkin D, Stevens M, Feldman EL. Protective effects of cyclooxygenase-2 (cox-2) gene inactivation against intraepidermal nerve fibers loss and peripheral nerve dysfunction in long-term experimental diabetes . 7 th International Symposium of Diabetic Neuropathy of the International Diabetes Federation . Cape Town , South Africa , Nov-Dec 2006.
31. Rodica Pop-Busui: Prevalence of Diabetic Peripheral Neuropathy (DPN) and Relation to Glycemic Control Strategies at Baseline in the BARI 2D Cohorts. Oral presentation at the 67 th American Diabetes Association Annual Meeting, Chicago IL , June 2007.
32. Rodica Pop-Busui: Rosiglitazone Ameliorates Nitrosative Stress and Inflammation in Type 2 Diabetes. Poster presentation at the 67 th American Diabetes Association Annual Meeting, Chicago IL , June 2007
33. Rodica Pop-Busui: Rosiglitazone Ameliorates Nitrosative Stress and Preserves Myocardial Blood Flow in Type 2 Diabetes. Oral presentation at the 17 th Annual Meeting of the NEURODIAB, September 2007, Utrecht , The Netherlands.
34. Rodica Pop-Busui: Cardiac Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC). Oral presentation at the 68 th American Diabetes Association Annual Meeting, San Francisco , CA , June 2008.
1. Pop-Busui R, Bacanu GH. Postural hypotension --a simple tool in detection of diabetic autonomic neuropathy. Timisoara Medicala 3:1991.
2. Bacanu GH, Serban V, Pop-Busui R, Negrisanu G, Bordos D. The diabetic foot. Acta Diabetica Romania. 21:47. 1993.
3. Sporea I, Pop-Busui R, Goldis A. Ultrasonographic assessment of gastric emptying in patients with diabetic autonomic neuropathy. Romanian Journal of Gastroenterology. 8:121-123. 1994.
4. Bacanu GH, Pop-Busui R, Serban V, Timar R. Arterial hypertension and diabetes mellitus. Romanian Revue of Modern Medicine. 9, 1996.
5. Pop-Busui R, Chey W and Stevens MJ. Severe Hypertension Induced by the Long-Acting Somatostatin Analogue Sandostatin LAR in a Patient with Diabetic Autonomic Neuropathy. Journal of Clinical Endocrinology & Metabolism. 85(3):943-946, March 2000.
6. Pop-Busui R, Sullivan K, Van Huysen C, Bayer L, Beyer L, Cao X, Towns R, Stevens MJ. Depletion of taurine in experimental diabetic neuropathy: implications for nerve metabolic, vascular and functional deficits. Experimental Neurology. 167, February 2001.
7. Rodica Pop-Busui, Marinescu V, Van Huysen C, Li F, Sullivan K, Greene DA, Larkin D, and Stevens MJ. Dissection of Metabolic, Vascular and Nerve Conduction Interrelationships in Experimental Diabetic Neuropathy by Cyclooxygenase Inhibition and Acetyl-L-Carnitine Administration. Diabetes 51: 2619-2628. 2002.
8. Rodica Pop-Busui, Kirkwood I, Schmid H, Marinescu V, Schroeder J, Larkin D, Raffel D and Stevens MJ. Sympathetic dysfunction in type 1 diabetes: association with impaired myocardial blood flow reserve and diastolic dysfunction. Journal of the American College of Cardiology. 44 (12): 2368-2374. 2004
9. Aaron Kellogg and Rodica Pop-Busui. Peripheral nerve dysfunction in Experimental Diabetes is mediated by Cyclooxygenase-2 and Oxidative Stress. Antioxidants & Redox Signaling. Nov 2005, Vol. 7, No. 11-12: 1521-1529.
10. Nakashima E, Rodica Pop-Busui, Towns R, Thomas TP, Hosaka Y, Nakamura J, Greene DA, Killen P, Schroeder J, Larkin D, Lam Ho Y and Stevens MJ. Regulation of the Human Taurine Transporter by Oxidative Stress in Retinal Pigment Epithelial Cells Stably Transformed to Overexpress Aldose Reductase. Antioxidants & Redox Signaling. Nov 2005, Vol. 7, No. 11-12: 1530-1542.
11. Rodica Pop-Busui, Sima AA, Stevens MJ. Diabetic Neuropathy and Oxidative Stress. Review. Diabetes, Metabolism, Research and Reviews. 2006; 22: 257–273.
12. Rodica Pop-Busui. Lamotrigine for Treatment of Pain Associated with Diabetic
Neuropathy: Results of Two Randomized, Double-Blind, Placebo-Controlled Studies. Nature Clinical Practice-Neurology. 2007; Vol.3, No 8: 424-425.
13. Albers JW, Herman WH, Rodica Pop-Busui, Martin CL, Cleary P, Waberski B. Subclinical Neuropathy among Diabetes Control and Complications Trial Participants
without Neuropathy at Trial End. Possible Predictors of Incident Neuropathy. Diabetes Care. 2007; 30(10):2613-16.
14. Kellogg AP, Wiggin T, Larkin D, Hayes J, Stevens M and Rodica Pop-Busui. Protective Effects of Cyclooxygenase-2 Gene Inactivation against Peripheral Nerve Dysfunction and Intraepidermal Nerve Fibers Loss in Experimental Diabetes. Diabetes. 2007, 56 (12):2997-3005
15. Kellogg AP, Cheng HT and Rodica Pop-Busui. Cyclooxygenase-2 Pathway as a Potential Therapeutic Target in Diabetic Peripheral Neuropathy. Curr Drug Targets. 2008 Jan;9(1):68-76.
16. Heung and Rodica Pop-Busui. Multidisciplinary Approach to the Management of Diabetes Complications. Review of Endocrinology, October 2007, Vol 1, No5, 30-34.
17. Matthew G. Field; VM. Elner; DG. Puro; J Feuerman; D C. Musch; Rodica Pop-Busui;
R Hackel; J R. Heckenlively; Howard R. Petty. Rapid, Non-invasive Detection of Diabetes-Induced Ocular Metabolic Stress (Archives of Ophthalmology, 2008, 126 (7):1-5.
18. Khanderia U, Rodica Pop-Busui, Eagle K. Thiazolidinediones in Type 2 Diabetes: A Cardiology Perspective. (Submitted to American Heart Journal).
19. G Pambianco, M Lombardero, V Bittner, Alan Forker, F Kennedy, A Krishnaswami, A Mooradian, Rodica Pop-Busui, J Rana, A Rodriguez, M Steffes, T J Orchard. Control f Lipid at Baseline in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial (Submitted to American Heart Journal)
20. Rodica Pop-Busui, E Oral, S Pennathur , D Raffel, J Byun, V Bajirovic, A Vivekanandan, A Kellogg, and MJ. Stevens. Impact Of Rosiglitazone And Glyburide On Nitrosative Stress And Myocardial Blood Flow Regulation In Type 2 Diabetes: A 6 Month Randomized Trial (Submitted European Journal of Clinical Investigation).
1. Rodica Pop-Busui. The Porphirias in: Little Textbook of Metabolic Diseas edited by Serban V. Excelsior Edit, Timisoara, Romania, pp. 143-157. 1994.
2. Stevens MJ, Rodica Pop-Busui, R, Greene DA, Feldman EL: Pathogenesis of Diabetic neuropathy. In: Porte D Jr, Sherwin R, Rifkin H (eds): Ellenberg and Rifkin's Diabetes Mellitus, 6th edition ( Stamford , CT : Appleton & Lange, 2002).
3. Rodica Pop-Busui and Stevens MJ: Animal models of diabetic neuropathy". In: Cheta D (Ed) "New Insights in Experimental Diabetes", Romanian Academy Printing House. Pp. 277-330. 2002.
4. Rodica Pop-Busui and Stevens MJ: Insulin and Cardiovascular Disease in Type 2 Diabetes. In: Cheta D (Ed) “Vascular Involvement in Diabetes: Clinical and Experimental Data” Romanian Academy Printing House & S. Karger AG; Bucharest & Basel , 653- 658, 2005.
5. Rodica Pop-Busui: New Drugs for Diabetes. In Hancu N, De Leiva A ( Ed). Pharmacotherapy of Diabetes Mellitus: Evidence and Controversies. Springer Verlag: Berlin , New York . 2006 (In press).
6. Rodica Pop-Busui, London , Z, Kellogg, A. Diabetes and Endocrine Disorders. In Gilman S (Ed). Neurobiology of Disease. Elsevier Academic Press. Elsevier Inc. 669-680. 2007.
7. Rodica Pop-Busui, Sullivan K, Feldman EL. Diabetes and the Nervous System. In Neurology and General Medicine, 4th Edition, Chapter 21. Aminoff MJ, editor. Elsevier, Philadelphia , PA , 2008, 383-408.
8. Rodica Pop-Busui, Simmons Z, Feldman EL. Treatment of Diabetic Neuropathy- The Evidence Based. In Herman W (Ed). Wiley Publications.( In press).
9. Rodica Pop-Busui and Martin Stevens. Detection and Treatment of Chronic Complications. In Medical Management of Type 2 Diabetes, 6 th Edition, Burant CF editor, American Diabetes Association Inc, 2008, 105-138.
